Peptic Digestion of Human and Bovine Lactoferrin

Gastric digestion of bovine lactoferrin in vivo in adults.

Lactoferrin (LF), an iron-binding glycoprotein present in milk and other endocrine and exocrine secretions, may exert a number of physiologic effects in the intestines. To study the effects of oral LF supplementation in vivo in the gastrointestinal tract, information about the gastric survival of LF in vivo is important. We tested 12 healthy volunteers (age 21 +/- 0.3 y) on 3 separate d accordi...

The peptic digestion of ribonuclease.

The nature of the final products resulting from the proteolysis of proteins is determined to a large degree by the conditions of temperature, time of incubation, and hydrogen ion concentration employed during digestion. Thus, Linderstrgm-Lang and Jacobsen (1) have demonstrated a two-phase digestive process in the case of the system, p-lactoglobulintrypsin, the initial phase preponderating at 0”...

Anticancer Effect of Bovine Lactoferrin on Human Esophagus Cancer Cell Line

Background: Lactoferrin (Lf) is a glycoprotein, a member of the transferrin family.From ten known mechanisms of anti-cancer chemoperotecive compounds, Lf alone, has six of these functions and inhibits cancer. In this study, the effect of lactoferrin purified from bovine colostrum was studied as an anti-cancer agent on esophageal cancer cell line. Materials and Methods: Bovine colostrum were ...

Isolation and characterization of some fragments obtained after peptic digestion of bovine serum albumin.

Recombinant human intelectin binds bovine lactoferrin and its peptides.

Intelectin (IntL), a lectin that exists on the brush border membrane of the small intestine, plays a role in the innate immune response and also acts as a receptor for lactoferrin (LF), an iron-binding glycoprotein found in milk and other secretions. Similar to human LF (hLF), bovine LF (bLF) has been shown to induce proliferation and differentiation of human enterocytes and to modulate their c...